Something old and something new: ENaC & TMEM16A as targets to hydrate mucus in the CF airway
Something old and something new: ENaC & TMEM16A as targets to hydrate mucus in the CF airway Henry Danahay, Enterprise Therapeutics, Brighton, UK In the absence of functional CFTR in the apical membrane, the epithelial sodium channel (ENaC) and TMEM16A, a calcium activated chloride channel, are key regulators of airway mucosal hydration. As drug targets, […]