ECFS Clinical Meeting Liverpool TMEM16A potentiator Objectives: TMEM16A (ANO1) is a Ca2+-activated, alternative chloride channel expressed in the human airway epithelium. A potentiator of TMEM16A is predicted to enhance the secretion of chloride and thereby increase mucus hydration and clearance in the CF lung. Our aim is to discover and test the efficacy of novel […]
A systematic comparison of the profiles of inhaled ENaC blocker candidates on mucociliary clearance: are we under-dosing in clinical studies? Henry Danahay1, Clive McCarthy1 and Martin Gosling1 1Enterprise Therapeutics, UK Objectives: Recent clinical studies with ENaC modulator compounds have challenged the validity of the target for treating CF lung disease. Our aim was to establish […]
Something old and something new: ENaC & TMEM16A as targets to hydrate mucus in the CF airway Henry Danahay, Enterprise Therapeutics, Brighton, UK In the absence of functional CFTR in the apical membrane, the epithelial sodium channel (ENaC) and TMEM16A, a calcium activated chloride channel, are key regulators of airway mucosal hydration. As drug targets, […]
The pharmacology of novel TMEM16A potentiator compounds Henry Danahay1,2, Sarah Lilley1, Holly Charlton1, Roy Fox1, Brian Button3, Martin Gosling1,2 1University of Sussex, Brighton, UK; 2Enterprise Therapeutics, UK; 3University of North Carolina, Chapel Hill, USA TMEM16A was recently identified as a calcium-activated chloride conductance and a key orchestrator of anion secretion in the human airway epithelium […]
TMEM16A channel function does not influence goblet cell numbers in the human airway epithelium Henry Danahay1,2, Martin Gosling1,2 1University of Sussex, Brighton, UK; 2Enterprise Therapeutics, UK. A role for the calcium activated chloride channel, TMEM16A, in the regulation of airway goblet cell populations has been recently reported (Kondo et al., 2017; Lin et al., 2015; […]
EACT increases intracellular calcium levels by a TMEM16A-independent mechanism Sarah Lilley1, Henry Danahay1,2, Holly Charlton1, Kathryn Adley1, Roy Fox1, Martin Gosling1,2 1University of Sussex, Brighton, UK; 2Enterprise Therapeutics, UK The N-aroylaminothiazole EACT was first described by Namkung et al. (2011) as an activator of the calcium-activated chloride channel, TMEM16A. Subsequently, EACT has been used as […]
Appointment brings significant commercial pharma experience as Enterprise Therapeutics’ two lead respiratory programmes are progressed towards the clinic Brighton, UK, 25 March 2019: Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives of patients suffering with respiratory disease, today announced the appointment of Amit […]
Identifying pathways & compounds regulating goblet cell metaplasia in vitro Henry Danahay1, Roy Fox2 and Martin Gosling1 1Enterprise Therapeutics, UK; 2University of Sussex, UK It is widely accepted that the composition of mucus in the CF airway, and the hydration status, significantly affects its clearance and thereby the potential for form plugs, restrict airflow and […]
Scrip Awards 2018 “Financing Deal of the Year- Private” category Lifestars Awards 2018 “EU Private Finance Raise of the Year <£30M” category Brighton, UK – 02 October 2018: Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the research and development of novel therapies for the treatment of respiratory diseases, has recently been announced as […]
Submission: 210 – PHARMACOKINETIC AND PHARMACODYNAMIC PROFILE OF A NOVEL INHALED ENAC BLOCKER, ETD001 Henry Danahay1, Clive McCarthy1, William Abraham2, Holly Charlton3, Sarah Lilley3, Roy Fox3 and Martin Gosling1 1Enterprise Therapeutics, UK; 2Mount Sinai Medical Center, USA; 3University of Sussex, UK Inhaled drugs are typically cleared very rapidly from the airway mucosa. Inhaled […]
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